The first DNA topoisomerase was discovered in bacteria by James C. Wang in 1971 and was initially named ω (omega) protein; [3] it is now called Escherichia coli (E. coli) topoisomerase I …

Nov 25, 2023 · Topoisomerases, or DNA topoisomerases, are enzymes that create single or double-stranded nicks in DNA during its replication or transcription to relieve the stress in a …

Feb 27, 2023 · Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination. It was first found by …

DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism.

Feb 28, 2022 · DNA topoisomerases are present in all domains of life to resolve a wide variety of topological problems arising from the length of the human double-helix DNA polymer (about 3 …

DNA topoisomerases are enzymes that control and modify the topological states of DNA. Two basic types of DNA topoisomerases have been found in nature. They are distinguished by the …

DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism.

DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or …

Topoisomerases are a class of enzymes that play a crucial role in DNA metabolism. Their primary function is to regulate the topological state of DNA by introducing temporary breaks in the DNA …

Jul 23, 2025 · Topoisomerases are nucleases that break the phosphodiester bonds in DNA reversibly. Topoisomerases function to relieve the positive supercoiling that arises from DNA …